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KMID : 1134819990280040912
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 4 p.912 ~ p.916
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Effect of Saponin from the Shoot of Aralia elata in Normal Rats and Streptozotocin Induced Diabetic Rats
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Kim Young-Hee
Im Jung-Gyo
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Abstract
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The purpose of this study was to investigate the effect of saponin in the shoot of Aralia elata on serum lipid level and glucose in streptozotocin(STZ)-induced diabetic rats. Sprague-Dawley normal male rats weighing 70±5g were randomly assigned to normal(control group), crude saponin(S group), and shoot of Aralia elata(D group). Experimental diets have been fed for 6 weeks. STZ-induced diabetic rats were classified to diabetic control(DC group) and crude saponin(DS group). Diabetic rats were experimentally induced by intravenous injection of STZ(65㎎/㎏ of body weight) dissolved in citrate buffer(pH 4.5). DS group has been i.p. injected with crude saponin solved in phosphate buffer(pH 7.0, 10㎎/100g body weight) and DC group fed for 10 days. Body weight decreased significantly in crude saponin group. Feed intakes and feed efficiency ratio were not significantly different among C, S, and D group. The crude saponin group has indicated the lowest values of serum total cholesterol, glucose, and triglyceride. However, the values of serum glucose and triglyceride were not significant. Insulin levels among the crude saponin group, the shoot powder group, and the control group were not significantly different. When STZ-induced diabetic rats have i.p. injection of crude saponin, the crude saponin has reduced the serum glucose but it is not been significant.
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KEYWORD
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Aralia elata, saponin, diabetic rats, cholesterol, glucose
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